Hemostasis
Plateletworks
Tags: Hemostasis
Plateletworks effectively determines functional platelet count and true platelet aggregation or inhibition using traditional ADP, Collagen or Arachidonic Acid agonists. All that’s needed is an impedance cell counter and Plateletworks reagent tubes to screen pre-surgical and trauma patients for adequate platelet function and to monitor effects of anti-platelet therapies.
The Plateletworks methodology is an adaptation of platelet aggregometry, using a cell counter to measure the total platelet count in a whole blood sample and then to redetermine the platelet count on a second sample that has been exposed to a known platelet agonist, such as Collagen or ADP, if clopidogrel response is being evaluated).
The agonist will stimulate those platelets that are functional to aggregate into clumps, and they will not be counted as platelets in the second sample. The difference in the platelet count between samples one and two provides a direct measurement of platelet aggregation and is reported as percent aggregation. Platelets rendered inactive or non-functional by aspirin or clopidogrel do not aggregate.
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